Cdc7 inhibitor 7c( Cdc7-IN-7c | Cdc7 IN 7c | Cdc7IN7c | Cdc7 inhibitor 7c )

Catalog No. M11315 CAS No. 1330781-04-8

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Datasheet

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HPLC

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Product Name

Cdc7 inhibitor 7c
Note

Research use only, not for human use.
Brief Description

A highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively.
Description

A highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively; exhibits significant time-dependent Cdc7 inhibition with slow dissociation kinetics, cellular pharmacodynamic (PD) effects, and COLO205 growth inhibition.
In Vitro

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In Vivo

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Synonyms

Cdc7-IN-7c | Cdc7 IN 7c | Cdc7IN7c | Cdc7 inhibitor 7c
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

Cancer
Indication

——

CAS Number

1330781-04-8
Formula Weight

315.395
Molecular Formula

C15H17N5OS
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1C2=C(C=C(C3=CNN=C3C)S2)N=C(CN4CCCC4)N1
Chemical Name

6-(3-methyl-1H-pyrazol-4-yl)-2-(pyrrolidin-1-ylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one

1. Kurasawa O, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3658-3670.

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